A deeper dive into NFLGSIS stats shows that the Colts are tied for first in unique starting offensive lineups this year with 13. The Jets, Eagles, Vikings, Browns, Bills and Cardinals have also needed 13 different starting lineups for one reason or another. For a reference point, the Rams and 49ers have had the fewest starting lineups (8). It's not necessarily indicative of success.
Of course, the Colts are not simply a team with a bad, oft-injured offensive line. They've invested heavily at the position over the years but have struggled to see their prospects grow beyond lofty rookie expectations.