1. @ Green Bay
2. @ Dallas
3. Detroit
All three are important wins for playoff seeding purposes. As much fun as it would be to beat Pittsburgh, I'd rather lose to them than lose to either of the 3 I listed and be stuck on the outside of the playoffs or lose the tiebreaker on a home playoff game.
The NFC West has been arguably the best division in football for the last 3 years. This year it will take a step back with implosion of SF. AZ and STL are threats but are the type of teams that are very likely to finish under .500. I could see us have a NE type run in this division for the next 5 years. Kapernick, Foles, and Palmer have to be replaced before I will be worried about losing our division reign.
Our 3 most likely losses this year are @ GB, @ Balt, and @ Dal
Last season I wanted to beat GB, DEN, and SF.