I'm iffy on this game against the 49ers. I think the good guys should win at home, but Harbaugh with time to plan worries me (though I have faith that our guys did some solid off-season planning for this game, too).
However, I really like how our schedule shakes out. I think that Carolina game might be the third-hardest road game we have behind @ATL and @SF. I think the Giants, Texans, and Colts can be had on the road, and I would gladly take a split @ARZ and @STL. Plus, consider that other than NO, no one else even has a shot at beating this team at home barring injury catastrophe (and I think NO doesn't have a great chance). Beat SF, and it should be 8-0.
Again, I think the NFC is so good that 12-4 can win HFA. If they can beat the 49ers at home, I can see 12-4 maybe happening, actually. We would only need to go 3-4 in our remaining road games. We have Clem and Avril coming back and Harvin was talking about being back Week Seven. This team will get stronger as the season goes along, hopefully.
But yeah, this game is another huge test to start the season. Get past this, and I will feel really good.