I am not a fan of the Air Raid in the NFL, you better have a very good O line the defense knows you will be in shotgun which takes away any element of surprise and it is common that the offense likes to score as quickly as possible this leaves your defense on the field longer which will exhaust them in the 2nd half and heaven forbid the offense gets a 3 and out
i believe in complimentary football with the offense and defense working together You could build your defense that the team will play with a lead having a rotation of pass rushers not as concerned with stopping the run