Here are the main things that I'm personally keeping an eye on ...
1) First and foremost -- no significant injuries. Please, can we just keep this squad healthy and intact for the most part?

ray:
2) Offensive Line. This is the biggest thing I'm going to be keeping my eye on (both in terms of the running game and their pass protection). This Vikings Defensive Line is one of the best in the league, so I'm intrigued by how they play. Specifically ...
A) going to be watching George Fant with a keen eye on how he handles Everson Griffin.
B) I'm intrigued to see the continued battle at the RG and RT spots. Aboushi, Glowinski, and Ethan Pocic. I'm REALLY enamored by Pocic and would be fairly dismayed if he isn't starting somewhere come Week 1. I LOVE what Pocic brings to the table.
3) I'm fascinated to see the continued battle for the final WR spots. Specifically, I'm looking forward to seeing If Kasen Williams can continue to make plays against a better secondary. I'm also hoping to see more from David Moore and am curious to see if Darboh can overcome that sternum issue and see some playing time.
4) Shaq Griffin -- I'd love to see him continue to progress and shut down these receivers of Minnesota.
5) I'm very interested to see Tramaine Brock in action. Is he going to end up seeing playing time ... and if so, how does he look in that Nickel Corner role?
6) The battle for the final RB Spot between Chris Carson, Alex Collins, and now Mike Davis. How do these guys all look tomorrow? I'm personally really love Carson and am pulling for him to make some noise, run over some guys tomorrow night, and continue to make YAC.
7) Trevone Boykin -- he had a strong performance against the Chargers. Can he continue to get better at going through his progressions quicker and to just make plays against a much stronger defense in Minnesota? Another solid performance will go a long ways towards cementing his place as this team's backup QB this year.