Great post and interesting video. Here are the differences between Wilson and RG3 as zone read runners.
#1: Wilson has very few QB keepers that were designed that way before the snap. By contrast, for Griffin there are a lot of "play action" type keepers that really weren't read options at all.
#2: Seattle only runs read option 20% of the time.
#3: Griffin is a very talented runner, but also very aggressive. Wilson is fast but extremely conservative. Wilson will give up a couple yards to take a safer slide. Even when RG3 slides, he usually does so at the last instant and still takes a hit. In the red zone, Wilson will only run it in when he knows he has an easy, contact free TD. Griffin is more like Jake Locker, he lowers the shoulder and hulks his way through. This is nice because it's resulted in quite a few TDs, but probably impacts his long term health and might not be worth it in the long run.
#4: Wilson does a lot of thinking before he decides to run. He might be the NFL's least decisive runner among the read option QBs. Kaepernick is the most decisive. RG3 is a close 2nd. Decisiveness is good for rushing effectiveness, but decisive QBs also call their number a few times a game when they shouldn't and take a hit as a result. Again, this is an area where Wilson keeps things conservative.
#5: I'd guess that least half of Wilson's rushes last year started off as passing plays. He really is more of a scrambler than a rusher. In terms of mobility, he's more like (a faster) Aaron Rodgers than Colin Kaepernick. RG3 scrambles on pass plays too, but it is less of his rushing total.
#6: Wilson is short, but has excellent BMI/bulk. He has a virtually spotless injury history. He knows how to protect his body and has a talent for taking glancing blows- he's drawn a lot of comparisons to Barry Sanders for how he takes a hit. RG3 has long, skinny legs, high, wobbly looking knees, and very little talent for sliding. In a lot of cases, he'll curl up in the fetal position and slide leading with the back of his head. Not smart. RG3 had an awful injury history coming out of college, so last year really shouldn't be a surprise. He needs to evolve his game or the Michael Vick comparisons will come true.
#7: RG3 is a strider, Wilson is more fluid. RG3 is faster, but Wilson is more elusive.
If the NFL played flag football, RG3 would be the league MVP without a doubt. He's got so much talent for both running and passing the ball. Really his only problem sometimes is decision making (as a runner) and having a body that is designed more for the Olympics than football. I think RG3 can be a very good pocket passer so I'm not worried about his future, and he's an extremely bright guy so I'm guessing he'll adapt much faster than people expect.