This is why the NFL has lost respect over the years
I think the NFL has lost respect over the years. There are multiple reasons for that rather than just 1 reason. Those reasons include the multiple changes in playing rules, changes to the playoff structure, the diversity in tv/streaming options, the cost of buying tickets, the NFL's historical position in relation to safety concerns, games being played overseas, and of course the introduction of TNF.
Overall the quality of TNF games hasn't matched the quality of other games. This is mostly because player recovery time and game preparation time are inevitably reduced. The introduction of a Wednesday Night game is significant because it finally allows for team to have a bye-week prior to a mid-week game. Effectively teams will have a 10-day entry into WNF and an 11-day exit into the next Sunday game. I believe this principle will be expanded for TNF with an 11-day entry and 10-day exit. I believe this is beneficial over having a 14-day period between games at a random point during the season.
I believe the NFL will extend the season by 1 week to have 17 games over 19 weeks. This will result in all teams having 2 mid-week games each season. That extra week would create an additional 5 games for TNF, Sunday 13:00, Sunday 16:25, SNF, and MNF. Additionally there could be 15 or 16 WNF games. It's a huge amount of potential extra revenue without increasing the number of games or reducing player safety.
I wouldn't expect such a change to be immediately popular. Almost every change in the NFL has been resisted, at least initially.