Hawk Finn":2ubwh1do said:
KiwiHawk":2ubwh1do said:
Seafan":2ubwh1do said:
I believe you meant to say "epilepsy" not MS.
No I meant what I typed. Had a co-worker got king-hit and subsequently developed MS. I thought the trauma merely precipitated a diagnosis, but it's possible that the trauma initiated the processes that lead to MS (possibly by compromising he blood/brain barrier), or accelerated the clinical onset of a latent case of MS.
Either way, I am sure my co-worker was not an isolated incident, so it's therefore possible that if a similar set of circumstances exist in Malik's case, a similar outcome could theoretically happen.
Again, I hope not. There's just such a cloud of mystery over the whole thing.
Head trauma does not cause MS. There is zero credible evidence suggesting otherwise. Please stop.
Multiple Sclerosis is an autoimmune disease, it has nothing to do with the blood/brain barrier. How do you propose head trauma caused an autoimmune reaction (antibodies, complement activation, etc). Your co-worker more likely had undiagnosed MS which produced insignificant symptoms prior to the head trauma that progressed afterwards.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077695/
"Conclusions
The method used, record linkage, ensures that patients' recollection of injury, or any tendency to attribute MS to injury, cannot have influenced the results.
Injuries to the head were not associated with either the aetiological initiation or the clinical precipitation of onset of multiple sclerosis."
https://www.sciencedirect.com/science/article/pii/S0022510X13028608
5. Conclusion
In the meta-analysis of the four cohort studies, pooled results did not support a statistical association between head trauma and the later diagnosis of MS. The result of the meta-analyses of high quality case–control studies however, suggests a statistically significant association between premorbid head trauma and the risk for developing MS. More specifically, those with premorbid head trauma were significantly more likely to be diagnosed with MS in comparison to those controls of similar age and sex who had not sustained head trauma.
Despite this significant finding, this in no way suggests or demonstrates causality, in that epidemiological studies can only provide etiological clues at best. More rigorous prospective studies, with high statistical power, are needed to convincingly establish an association between trauma and MS. Future prospective studies that take into consideration (a) the long latency period between the age of putative biological onset and clinical onset of MS, (b) define trauma based on validated instruments, (c) include frequency of traumas per study participant, and (d) include information on the site of trauma and MRI of the lesion are needed in order to definitively rule out any causal links between physical trauma and MS.