to the first two points (and i think they're accurate), soooo much of the ability of a qb to anticipate his wr being open or to throw him open depends on the relationship the QB has with his OC and how aligned they are and studied he is in a consistent philosophy and game-plan week in and week out. Its true, that reading a defense is reading a defense, so one could argue that it doesnt matter what 'style' of offense you run, what matters is being able to understand man / zone looks and 'see' the areas of the field that will be open. But there's a difference between dictating the terms of engagement and just calling plays. The great playcaller, qb combinations in the league make it easy on themselves by constantly forcing the defense they're playing to second guess what they're seeing. When that starts to happen, the anticipatory part of the QBs game becomes much easier. And the more that QB is in those situations where things are flowing, the more the offense expands, and his grasp of the game grows. It becomes a reflexive, 'if this, then that' series of decisions that become second nature
Lock has NEVER had that opportunity to not just learn under a solid offensive mind, but to establish a relationship with his OC and develop the close bond that playcaller and QB need. So its hard to say that Lock cant do those things. It looks like he cant right now because the Denver offense was never good enough to actually tip the table and keep secondaries guessing. He mentioned specifically the connection he had with his first OC his rookie year and how it reflected in his play and how hard it was transitioning the following year. i think that's notable. He was 4-0 in the offense he felt comfortable in and looked every bit the budding star folks thought he'd be.
If he can develop the above, his pocket awareness and ability to extend plays will improve as well. If he knows where to be in the pocket and can anticipate where the open guy will be play in and play out, and where pressure is coming from, he'll also be able to make quick decisions as to when it makes sense to move himself outside or just take off and scramble for a few yards. Aaron Rodgers isnt an elusive, scrambling QB, but when he pulls the ball down, its usually not on designed runs, but rather is entirely based on his understanding, pre-snap that there's a high prpbability that the run will be there.