- Where: Lumen Field | Seattle
- When: 8:20 p.m. ET on Monday, Sept. 12
- How to watch: ESPN/ABC
The league schedule makers didn't let Russell Wilson's return to Seattle linger. Week 1 will conclude with the nine-time Pro Bowl quarterback's anticipated return to play his old squad, which traded him to the Broncos in the offseason. Wilson, who will officially become the first quarterback to play for a team he previously defeated in a Super Bowl when he suits up for Denver, will also become just the fifth quarterback in NFL history to win at least 100 games with a franchise and then play against them. Emotions and anticipation are sure to be high before, during and after this one, as the buildup, the game and the postgame handshake between Wilson and Pete Carroll are all sure to be must-see TV.
Also Announced Week 2 @ Niners
- Where: Levi's Stadium | Santa Clara, Calif.
- When: 4:05 p.m. ET on Sunday, Sept. 18
- How to watch: FOX
San Francisco enters 2022 with lofty expectations after a run to the NFC Championship Game, but when it faces the rival Seahawks, there will be a far different feel. The 49ers are projected to have Trey Lance starting at quarterback rather than Jimmy Garoppolo, while the Seahawks won't have Russell Wilson starting a season for them for the first time in a decade. No matter who's under center, Kyle Shanahan's Niners are looking to snap a four-game losing streak to Pete Carroll's 'Hawks.
2022 NFL schedule release: Bills-Rams kicks off regular season; complete Week 1 schedule; all 32 home openers
The 2022 NFL regular season will kick off with a marquee showdown in Los Angeles as the Rams will host the Buffalo Bills on Sept. 8. Check the complete Week 1 schedule in addition to every team's home opener.