San Francisco 49ers: Defensive end Justin Smith (elbow) and outside linebacker Clark Haggans (shoulder) did not practice. Outside linebacker Ahmad Brooks (shoulder), cornerback Tarell Brown (shoulder), linebacker Tavares Gooden (ribs), receiver Mario Manningham (shoulder), running back Bruce Miller (shoulder), linebacker Aldon Smith (shoulder) and defensive lineman Will Tukuafu (concussion) did not practice Wednesday. Smith's status is a key variable given his 185-game starting streak and the 49ers' injury situation at the position. Other teams running 3-4 defenses tend to carry six or seven linemen on their 53-man rosters. The 49ers had greater flexibility when Tukuafu was healthy and before tight end Demarcus Dobbs, a former defensive lineman, landed on injured reserve. I found it telling that Smith returned to the game against New England for one play before departing. He's as tough and durable as they come. Kicker David Akers (pelvis), guard Alex Boone (knee), linebacker NaVorro Bowman (shoulder), running back Frank Gore (wrist), guard Mike Iupati (shoulder), cornerback Carlos Rogers (knee) and linebacker Patrick Willis (shoulder) were full participants.

Seattle Seahawks: Defensive tackle Alan Branch (ankle), defensive end Jason Jones (knee), running back Leon Washington (illness), receiver Sidney Rice (knee), cornerback Walter Thurmond (hamstring) and cornerback Marcus Trufant (hamstring) did not practice. Running back Marshawn Lynch (back) was limited. The already diminished depth at cornerback would become a bigger issue if the NFL were to suspend starter Richard Sherman following his hearing Friday regarding a four-game suspension for using performance-enhancing drugs. The league generally announces suspensions early enough in the week for teams to adjust their rosters in time for practices, however.