We've held up well against a pretty impressive string of offenses - Dallas, Green Bay, Carolina, New England. I'm not worried about the 49ers offense in the least. Davis is a monster, but nobody else scares me. Moss has all of 11 catches through six games. Crabtree is having a decent season, but our CB's will handle him.
You game plan to stop Gore and contain Davis. And with Joe Staley potentially out, the key will be pass rush. We can't let Alex Smith stay comfortable in the pocket. He's not a dangerous QB, but he is efficient.
I'm more concerned with how we are going to move the ball against them, but we managed to do it with T Jack so maybe there is hope.