I don't think you're as stacked as RB as you might. Best could be out for a long while with those concussions and could leave at any time. Miami can't decide if they want Bush or Thomas to be their feature back and Reggie is made of glass.
I would seriously target the Andre Johnson owner simply offering him Desean. I can tell you right now the AJ owner is probably sick of waiting for AJ to come back and now having Leinart throwing him passes, he's probably even more concerned. And as any DJax owner knows, he's one of the most frustrating fantasy assets around, as he disappears entirely from the fantasy radar some weeks, so you're never confident starting him. I think even with Leinart chucking the ball, I'd rather own AJ, and if all you need to move is DJax, I consider it a fairly low risk/high reward proposition for you.