Ive been commuting from Sammamish to Ellensburg 4 days a week for the last 8 months to finish up my last year in school. Its 200 miles round trip and takes about 3.5 hours.
I was dreading doing this before the school year, but it hasn't been nearly as bad as I thought it would be. I just put on sports radio and grab an energy drink and just enjoy the drive (in the morning). The drive back sucks because all you want to do is get home quickly. I have to deal with the pass too, but this year the snow has been really light, and I bought an all wheel drive car for my commute.
For me, I'm only doing this because there is light at the end of the tunnel. If is was for a job that I planned on keeping for who knows how long, I probably wouldn't do it.