Eliminate practice squad and go to a 60 or even 63 person roster. Why? The amount of active players ends up meaning that teams are carrying injured players on the active roster, and almost all team runs short at certain positions during the season. This increases injuries because of guys playing hurt, playing out of position, using poor technique because of their discomfort at a certain position, etc.
I think by adding even one more player to each position group, then the NFL would be showing that they are taking this seriously. They also would be showing the player's association that they want to pay an extra 300 guys a good salary per year. I realize this is the kind of thing that needs to be negotiated, but if the NFL proposed this to the union, then I can't imagine that it would be turned down as a modification.
After all of the good players I see that are cut each year at this time, I can see that there are enough good players to fill these roster spots. Even if it just means letting current practice squad players play on a "futures" type of contract (similar to the old Generation Adidas contracts in MLS that didn't count toward the cap, but helped to keep good players around as they developed).
I hope it happens. Let's expand rosters and stop going to the bare minimum and inactivate guys every week. This would especially benefit Seattle of course because of how good they are at drafting and finding talent, but it would be better for player safety. Less chance of having to re-insert a possible concussion, etc. I'd like to see a serious push for vastly expanded rosters and eligible players to play each week. We could carry 8 running backs if we wanted.
But seriously, the main reasoning is for the safety of players in my view.