Oh, undoubtedbly huge. The only question I have is how rusty he is going to be. He said while he was off that he emulated the Seahawks schedule so he would stay in synch with them. He also is one of the hardest working guys in practice (from reports in TC), so it's really only game rust that I'm worried about. He'll have some fresh legs, which will be really nice covering those quicker WRs; he'll have less mileage on him.
I think he's actually going to be huge on the outside this game. RGIII loves to bounce stuff outside in the run game. Browner should have the speed to close, as evidenced by his catch of AP from behind in that game. If Griffin isn't thinking about Browner lowering the boom on him from that side, he will the first time he gets hit. It could end up being a psychological factor.