In terms of body recovery I would certainly think so. The question will be how much of a factor will it be without having the normal recovery time.
If you look at the 2 teams the 49ers are certainly older especially at the top end. SEattle has 1 player who is 31- Tru, the rest are 30 and younger. Meanwhile 49ers have 9 players 31+.
They'll got 11 guys 30 or older including
Justin Smith- DL = 33
Issac Sopoaga- DL = 31
Carlos Rodgers- CB =31
Jonathan Goodwin- C = 33
Randy Moss- WR = 35
Brandon Jacobs- RB = 30
Ages 29, 28 (10 total) include- Alex Smith-QB, Ray McDonald-DL, Frank Gore- RB (29), Vernon Davis-TE, Ahmad Brooks-LB, Dashon Goldson.
Meawhile the Seahawks ahve 7 guys 30+
Chris Clemmons- DE= 30
Leon Washington- RET = 30
Marcus Trfaunt- CB= 31
Leroy Hill- LB = 30
7 more players who are 28,29 years old including- Edward -WR, McQuistan-OL, Robinson- RB, Browner, CB, Red Bryant, DT
SO it will be interesting to see which teams has fresher legs in this game, as well as brings the most intensity as both teams had pretty big games last week.