SF will be unable to concentrate after that beat down and will have lost their confidence, especially since we ran on them last year and ruined their quest for a rush defense season best.
The 49ers are the ones that will struggle and we'll do what we do best, intercept, sack, stop the run and run the ball down their throats until we have broken their spirit.
It will be harbaugh at the end of the day saying "what's your deal? how did you field such a good team during a rebuild and since i inherited a talented team?' Well except for the QB."
And Pete will say, I drafted 2 of your players right out from underneath you, that's my deal.