On the money fantasy league I play in, the points are heavily weighted towards TDs (pass, rec, rush). Ks are even valuable.
There's only a few WRs who consistently score TDs. Besides AP, Lynch & Charles, there's not a RB I covet.
If I'm picking 4th or below, I'm taking QB (Manning) in the first and then as the league continues to make runs on QBs and RBs, I take the #1 WRs (Megatron / AJ Green or TE JG).
By the the third round, I re-evaluate my standing. Are there no RBs left in the top 10? Good, I'll pick a top QB/WR/TE because one will be available.
I don't care about week 1, I'm a guy who lives for trades and free agency. RBs will get hurt, I will be able to pick one off the wire (this method also depends on how your wire is set-up).
If I'm picking in the top 3, I'll go relatively chalk, RB, QB, WR/TE.
I drafted three QBs last year (we also had a limited bench/roster space). I traded two of them and ended up with Lynch (who I eventually traded).
I lost in the championship round thanks to an unbelievable week by my opponent (who actually drafted AJ Green first).
I enjoy ruining threads by making them about personal attacks and then commenting about how personal attacks make the other person's argument invalid.