I would be a little surprised, and not because we are missing a 1st rounder.
#1: There are so many great players in this draft that even Matt Millen could probably hit a homerun this year. The team with the best draft will probably be the team with the most picks in the top 150, or close to it. If 49ers GM Trent Baalke doesn't come out of this draft without at least 4-5 good players from his 14 total picks, he's our new best friend.
#2: If Seattle drafted Armonty Bryant, I'd consider it one of the biggest steals in the draft. Then, 5 months later, Bryant might get cut after failing to make the 53 man. It could happen. This is the toughest roster to make in the NFL, so Seattle could kill the draft and nobody would know it because those picks didn't start or didn't even make the team.